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Histological observations on biopsies harvested following sinus floor elevation using a bioactive glass material of narrow size range

Identifieur interne : 008F19 ( Main/Exploration ); précédent : 008F18; suivant : 008F20

Histological observations on biopsies harvested following sinus floor elevation using a bioactive glass material of narrow size range

Auteurs : Ette S. Tadjoedin [Pays-Bas] ; Gert L. De Lange [Pays-Bas] ; Paulien J. Holzmann [Pays-Bas] ; Luit Kuiper [Pays-Bas] ; Elisabeth H. Burger [Pays-Bas]

Source :

RBID : ISTEX:6DE527582B61F6689DEC8C6BE6CFAE19B590AAF6

Descripteurs français

English descriptors

Abstract

We evaluated the bone augmenting capacity of bioactive glass particles, size range 300–355 μm (BG‐particles), in human sinus floor elevations using histomorphometrical methods. A total of 10 patients underwent bilateral grafting, using a 1:1 mixture of autogenous bone particles (from iliac crest) and BG‐particles at one side (experimental side), and bone particles only at the other side (control side, split mouth design). A total of 72 bone biopsies were taken at the time of fixture installation; that is, 3 patients at 4 months, 3 at 5 months and 3 at 6 months after grafting and 1 patient at 16 months (when she presented again). In each case 6 biopsies were taken, 3 left and 3 right. Histomorphometry showed that in grafts at control sides, trabecular bone was present after 4 months, comprising almost 41% of the tissue volume. This bone contained viable osteocytes and was of mature lamellar type and showed a mature histological appearance. Bone volume continued to increase slightly, to 42% at 5 months, 44% at 6 months and 45% at 16 months. The graft volume at experimental sides consisted at 4 months for 28% of woven and some lamellar bone, and increased to 35% at 5 months and 38% at 6 months, when mainly lamellar bone was found. At 16 months a lamellar bone volume of 45% was found. The BG‐particles transformed and became excavated with time, starting at 4 months, and their centers gradually filled with bone tissue. All BG‐particles had disappeared by resorption at 16 months after grafting and had been replaced by bone tissue. Parameters of bone turnover (% osteoid surface, % resorption surface, mineral apposition rate as measured by tetracycline labeling) indicated that bone remodeling was very active at both sides, during more than 6 months, despite the mature histological appearance of the bone tissue. From these histological observations, we conclude that a 1:1 mixture of autogenous bone/BG‐particles seems a promising alternative to autogenous bone only, when low amounts of bone tissue are available for sinus augmentation.

Url:
DOI: 10.1034/j.1600-0501.2000.011004334.x


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<term>Active bone</term>
<term>Apposition</term>
<term>Augmentation</term>
<term>Autogenous</term>
<term>Autogenous bone</term>
<term>Autogenous bone particles</term>
<term>Bioactive</term>
<term>Bioactive glass</term>
<term>Bioactive glass material</term>
<term>Bioactive glass particles</term>
<term>Biocompatible Materials (chemistry)</term>
<term>Biocompatible Materials (therapeutic use)</term>
<term>Bioglass implants</term>
<term>Biomedical materials research</term>
<term>Biopsy</term>
<term>Bone</term>
<term>Bone Matrix (pathology)</term>
<term>Bone Remodeling (physiology)</term>
<term>Bone Resorption (pathology)</term>
<term>Bone Substitutes (chemistry)</term>
<term>Bone Substitutes (therapeutic use)</term>
<term>Bone Transplantation (methods)</term>
<term>Bone biopsies</term>
<term>Bone formation</term>
<term>Bone formation parameters</term>
<term>Bone graft</term>
<term>Bone histomorphometry</term>
<term>Bone layer</term>
<term>Bone marrow</term>
<term>Bone particles</term>
<term>Bone reconstruction</term>
<term>Bone reconstructions</term>
<term>Bone regeneration</term>
<term>Bone surface</term>
<term>Bone tissue</term>
<term>Bone volume</term>
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<term>Control patient</term>
<term>Control side</term>
<term>Control sides</term>
<term>Demineralized freeze</term>
<term>Dental Implantation, Endosseous</term>
<term>Dental Implants</term>
<term>Dental implants</term>
<term>Dentistry</term>
<term>Donor site</term>
<term>Edentulous</term>
<term>Edentulous patients</term>
<term>Elevation histology</term>
<term>Empty lacunae</term>
<term>Endosteal implants</term>
<term>Entire graft</term>
<term>Experimental graft</term>
<term>Experimental side</term>
<term>Experimental sides</term>
<term>Female</term>
<term>Fluorescent Dyes</term>
<term>Follow-Up Studies</term>
<term>Furusawa mizunuma</term>
<term>Glass (chemistry)</term>
<term>Goldner</term>
<term>Goldner staining</term>
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<term>Granule</term>
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<term>Histological</term>
<term>Histological observations</term>
<term>Histology</term>
<term>Histomorphometric evaluation</term>
<term>Histomorphometry</term>
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<term>Hueso lamelar</term>
<term>Humans</term>
<term>Iliac crest</term>
<term>Implant</term>
<term>Implant dentistry</term>
<term>Implant placement</term>
<term>Implants research</term>
<term>International journal</term>
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<term>Lamellar bone</term>
<term>Lamellar type</term>
<term>Light micrograph</term>
<term>Light microscopy</term>
<term>Mature bone marrow</term>
<term>Mature histological appearance</term>
<term>Maxilla</term>
<term>Maxilla (surgery)</term>
<term>Maxillary</term>
<term>Maxillary Sinus (pathology)</term>
<term>Maxillary Sinus (surgery)</term>
<term>Maxillary bone</term>
<term>Maxillary sinus</term>
<term>Maxillary sinus augmentation</term>
<term>Maxillofacial implants</term>
<term>Maxillofacial surgery</term>
<term>Mesenchymal cells</term>
<term>Meses</term>
<term>Middle Aged</term>
<term>Mineral apposition rate</term>
<term>Mineralized tissue</term>
<term>Mois</term>
<term>Monaten</term>
<term>Month biopsy</term>
<term>Months biopsy</term>
<term>Months patient</term>
<term>Multinuclear giant cells</term>
<term>Nach</term>
<term>Narrow size range</term>
<term>Oral cell biology</term>
<term>Oral implantology</term>
<term>Oral rehabilitation</term>
<term>Oral surgery</term>
<term>Osteocyte</term>
<term>Osteocytes (pathology)</term>
<term>Osteogenesis (physiology)</term>
<term>Osteoid</term>
<term>Osteoid layers</term>
<term>Osteoid surface</term>
<term>Other side</term>
<term>Outer shell</term>
<term>Particle size</term>
<term>Patienten nach</term>
<term>Present study</term>
<term>Prozentualer anteil</term>
<term>Quatre mois</term>
<term>Resorption</term>
<term>Resorption surface</term>
<term>Restorative dentistry</term>
<term>Schepers</term>
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<term>Sinus</term>
<term>Size range</term>
<term>Split mouth</term>
<term>Standard deviation</term>
<term>Tejido oseo</term>
<term>Tetracycline</term>
<term>Thick layer</term>
<term>Tissu osseux</term>
<term>Tissue research</term>
<term>Tissue volume</term>
<term>Total bone volume</term>
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<term>Trabecular bone</term>
<term>Trabecular bone volume</term>
<term>Undifferentiated mesenchymal cells</term>
<term>Unstained section</term>
<term>Upper denture</term>
<term>Vrije universiteit</term>
<term>Xture installation</term>
<term>Xtures</term>
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<term>Adulte d'âge moyen</term>
<term>Biopsie</term>
<term>Colorants fluorescents</term>
<term>Femelle</term>
<term>Humains</term>
<term>Implant résorbable</term>
<term>Implants dentaires</term>
<term>Matériaux biocompatibles ()</term>
<term>Matériaux biocompatibles (usage thérapeutique)</term>
<term>Maxillaire ()</term>
<term>Mâchoire édentée ()</term>
<term>Ostéocytes (anatomopathologie)</term>
<term>Ostéogenèse (physiologie)</term>
<term>Pose d'implant dentaire endo-osseux</term>
<term>Remodelage osseux (physiologie)</term>
<term>Résorption osseuse (anatomopathologie)</term>
<term>Sinus maxillaire ()</term>
<term>Sinus maxillaire (anatomopathologie)</term>
<term>Substituts osseux ()</term>
<term>Substituts osseux (usage thérapeutique)</term>
<term>Trame osseuse (anatomopathologie)</term>
<term>Transplantation osseuse ()</term>
<term>Tétracycline</term>
<term>Verre ()</term>
<term>Études de suivi</term>
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<term>Biocompatible Materials</term>
<term>Bone Substitutes</term>
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<term>Biocompatible Materials</term>
<term>Bone Substitutes</term>
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<term>Ostéocytes</term>
<term>Résorption osseuse</term>
<term>Sinus maxillaire</term>
<term>Trame osseuse</term>
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<term>Glass</term>
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<keywords scheme="MESH" qualifier="methods" xml:lang="en">
<term>Bone Transplantation</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en">
<term>Bone Matrix</term>
<term>Bone Resorption</term>
<term>Maxillary Sinus</term>
<term>Osteocytes</term>
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<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr">
<term>Ostéogenèse</term>
<term>Remodelage osseux</term>
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<keywords scheme="MESH" qualifier="physiology" xml:lang="en">
<term>Bone Remodeling</term>
<term>Osteogenesis</term>
</keywords>
<keywords scheme="MESH" qualifier="surgery" xml:lang="en">
<term>Jaw, Edentulous</term>
<term>Maxilla</term>
<term>Maxillary Sinus</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr">
<term>Matériaux biocompatibles</term>
<term>Substituts osseux</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en">
<term>Absorbable Implants</term>
<term>Active bone</term>
<term>Apposition</term>
<term>Augmentation</term>
<term>Autogenous</term>
<term>Autogenous bone</term>
<term>Autogenous bone particles</term>
<term>Bioactive</term>
<term>Bioactive glass</term>
<term>Bioactive glass material</term>
<term>Bioactive glass particles</term>
<term>Bioglass implants</term>
<term>Biomedical materials research</term>
<term>Biopsy</term>
<term>Bone</term>
<term>Bone biopsies</term>
<term>Bone formation</term>
<term>Bone formation parameters</term>
<term>Bone graft</term>
<term>Bone histomorphometry</term>
<term>Bone layer</term>
<term>Bone marrow</term>
<term>Bone particles</term>
<term>Bone reconstruction</term>
<term>Bone reconstructions</term>
<term>Bone regeneration</term>
<term>Bone surface</term>
<term>Bone tissue</term>
<term>Bone volume</term>
<term>Connective tissue</term>
<term>Control patient</term>
<term>Control side</term>
<term>Control sides</term>
<term>Demineralized freeze</term>
<term>Dental Implantation, Endosseous</term>
<term>Dental Implants</term>
<term>Dental implants</term>
<term>Dentistry</term>
<term>Donor site</term>
<term>Edentulous</term>
<term>Edentulous patients</term>
<term>Elevation histology</term>
<term>Empty lacunae</term>
<term>Endosteal implants</term>
<term>Entire graft</term>
<term>Experimental graft</term>
<term>Experimental side</term>
<term>Experimental sides</term>
<term>Female</term>
<term>Fluorescent Dyes</term>
<term>Follow-Up Studies</term>
<term>Furusawa mizunuma</term>
<term>Goldner</term>
<term>Goldner staining</term>
<term>Graft</term>
<term>Granule</term>
<term>Hench</term>
<term>High density</term>
<term>Histological</term>
<term>Histological observations</term>
<term>Histology</term>
<term>Histomorphometric evaluation</term>
<term>Histomorphometry</term>
<term>Hueso</term>
<term>Hueso lamelar</term>
<term>Humans</term>
<term>Iliac crest</term>
<term>Implant</term>
<term>Implant dentistry</term>
<term>Implant placement</term>
<term>Implants research</term>
<term>International journal</term>
<term>Lamellar</term>
<term>Lamellar bone</term>
<term>Lamellar type</term>
<term>Light micrograph</term>
<term>Light microscopy</term>
<term>Mature bone marrow</term>
<term>Mature histological appearance</term>
<term>Maxilla</term>
<term>Maxillary</term>
<term>Maxillary bone</term>
<term>Maxillary sinus</term>
<term>Maxillary sinus augmentation</term>
<term>Maxillofacial implants</term>
<term>Maxillofacial surgery</term>
<term>Mesenchymal cells</term>
<term>Meses</term>
<term>Middle Aged</term>
<term>Mineral apposition rate</term>
<term>Mineralized tissue</term>
<term>Mois</term>
<term>Monaten</term>
<term>Month biopsy</term>
<term>Months biopsy</term>
<term>Months patient</term>
<term>Multinuclear giant cells</term>
<term>Nach</term>
<term>Narrow size range</term>
<term>Oral cell biology</term>
<term>Oral implantology</term>
<term>Oral rehabilitation</term>
<term>Oral surgery</term>
<term>Osteocyte</term>
<term>Osteoid</term>
<term>Osteoid layers</term>
<term>Osteoid surface</term>
<term>Other side</term>
<term>Outer shell</term>
<term>Particle size</term>
<term>Patienten nach</term>
<term>Present study</term>
<term>Prozentualer anteil</term>
<term>Quatre mois</term>
<term>Resorption</term>
<term>Resorption surface</term>
<term>Restorative dentistry</term>
<term>Schepers</term>
<term>Severe maxillary atrophy</term>
<term>Sinus</term>
<term>Size range</term>
<term>Split mouth</term>
<term>Standard deviation</term>
<term>Tejido oseo</term>
<term>Tetracycline</term>
<term>Thick layer</term>
<term>Tissu osseux</term>
<term>Tissue research</term>
<term>Tissue volume</term>
<term>Total bone volume</term>
<term>Trabecular</term>
<term>Trabecular bone</term>
<term>Trabecular bone volume</term>
<term>Undifferentiated mesenchymal cells</term>
<term>Unstained section</term>
<term>Upper denture</term>
<term>Vrije universiteit</term>
<term>Xture installation</term>
<term>Xtures</term>
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<term>Adulte d'âge moyen</term>
<term>Biopsie</term>
<term>Colorants fluorescents</term>
<term>Femelle</term>
<term>Histologie</term>
<term>Humains</term>
<term>Implant résorbable</term>
<term>Implants dentaires</term>
<term>Matériaux biocompatibles</term>
<term>Maxillaire</term>
<term>Mâchoire édentée</term>
<term>Pose d'implant dentaire endo-osseux</term>
<term>Sinus maxillaire</term>
<term>Substituts osseux</term>
<term>Transplantation osseuse</term>
<term>Tétracycline</term>
<term>Verre</term>
<term>Études de suivi</term>
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<div type="abstract" xml:lang="en">We evaluated the bone augmenting capacity of bioactive glass particles, size range 300–355 μm (BG‐particles), in human sinus floor elevations using histomorphometrical methods. A total of 10 patients underwent bilateral grafting, using a 1:1 mixture of autogenous bone particles (from iliac crest) and BG‐particles at one side (experimental side), and bone particles only at the other side (control side, split mouth design). A total of 72 bone biopsies were taken at the time of fixture installation; that is, 3 patients at 4 months, 3 at 5 months and 3 at 6 months after grafting and 1 patient at 16 months (when she presented again). In each case 6 biopsies were taken, 3 left and 3 right. Histomorphometry showed that in grafts at control sides, trabecular bone was present after 4 months, comprising almost 41% of the tissue volume. This bone contained viable osteocytes and was of mature lamellar type and showed a mature histological appearance. Bone volume continued to increase slightly, to 42% at 5 months, 44% at 6 months and 45% at 16 months. The graft volume at experimental sides consisted at 4 months for 28% of woven and some lamellar bone, and increased to 35% at 5 months and 38% at 6 months, when mainly lamellar bone was found. At 16 months a lamellar bone volume of 45% was found. The BG‐particles transformed and became excavated with time, starting at 4 months, and their centers gradually filled with bone tissue. All BG‐particles had disappeared by resorption at 16 months after grafting and had been replaced by bone tissue. Parameters of bone turnover (% osteoid surface, % resorption surface, mineral apposition rate as measured by tetracycline labeling) indicated that bone remodeling was very active at both sides, during more than 6 months, despite the mature histological appearance of the bone tissue. From these histological observations, we conclude that a 1:1 mixture of autogenous bone/BG‐particles seems a promising alternative to autogenous bone only, when low amounts of bone tissue are available for sinus augmentation.</div>
</front>
</TEI>
<affiliations>
<list>
<country>
<li>Pays-Bas</li>
</country>
<region>
<li>Hollande-Septentrionale</li>
</region>
<settlement>
<li>Amsterdam</li>
</settlement>
</list>
<tree>
<country name="Pays-Bas">
<region name="Hollande-Septentrionale">
<name sortKey="Tadjoedin, Ette S" sort="Tadjoedin, Ette S" uniqKey="Tadjoedin E" first="Ette S." last="Tadjoedin">Ette S. Tadjoedin</name>
</region>
<name sortKey="Burger, Elisabeth H" sort="Burger, Elisabeth H" uniqKey="Burger E" first="Elisabeth H." last="Burger">Elisabeth H. Burger</name>
<name sortKey="De Lange, Gert L" sort="De Lange, Gert L" uniqKey="De Lange G" first="Gert L." last="De Lange">Gert L. De Lange</name>
<name sortKey="Holzmann, Paulien J" sort="Holzmann, Paulien J" uniqKey="Holzmann P" first="Paulien J." last="Holzmann">Paulien J. Holzmann</name>
<name sortKey="Kuiper, Luit" sort="Kuiper, Luit" uniqKey="Kuiper L" first="Luit" last="Kuiper">Luit Kuiper</name>
</country>
</tree>
</affiliations>
</record>

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